Pomegranate juice protects kidneys from Cisplatin-induced nephrotoxicity
نویسندگان
چکیده
منابع مشابه
Grape seed proanthocyanidin extract protects from cisplatin-induced nephrotoxicity by inhibiting endoplasmic reticulum stress-induced apoptosis
Cisplatin (CP) is used as an antineoplastic drug in the clinic, but its nephrotoxicity limits its use. Grape seed proanthocyanidin extract (GSPE) is a powerful antioxidant. In this study, we investigated whether GSPE can prevent CP-induced nephrotoxicity and explored the underlying mechanism. Male C57/BL6 mice were randomly divided into four groups: control group (N), CP group (C), receiving an...
متن کاملPomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats
BACKGROUND Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats. METHODS Twenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for...
متن کاملEffect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats
BACKGROUND Chemotherapy with cisplatin (CP) is accompanied with nephrotoxicity. OBJECTIVES In the current study, pomegranate flower extract (PFE) has been evaluated as an antioxidant agent against CP-induced-renal toxicity. MATERIALS AND METHODS Thirty two male Wistar rats were divided into five groups (6-8 in each group). The animals in groups 1 to 3 received PFE (25 mg/kg), PFE (50 mg/kg)...
متن کاملpomegranate flower extract does not prevent cisplatin-induced nephrotoxicity in female rats
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متن کاملEffect of Simvastatin on Cisplatin-induced Nephrotoxicity in Male Rats
Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...
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ژورنال
عنوان ژورنال: Journal of the Faculty of Medicine Baghdad
سال: 2018
ISSN: 2410-8057,0041-9419
DOI: 10.32007/jfacmedbagdad.59470